研究方向
主要从事纳米医药研究。近年来研究兴趣主要集中在以下几个方面：（1） 阿尔兹海默综合症（老年痴呆症，AD）抑制剂的研究，针对AD的病理机制，设计制备了纳米载药体系，实现多靶点抑制阿尔兹海默症的功能，发现有可能成为AD候选药物的多功能纳米体系。（2）纳米载药体系治疗耐药细菌感染的研究，针对细菌的耐药机制，构建响应释放，消除细菌生物膜，激活免疫抑制微环境的仿生纳米体系，评价其体外、体内治疗耐药细菌感染的效果，阐明其不易产生耐药的抗菌机制。（3）绿色纳米农药的研究与开发，利用纳米载药，开展按需递送农药，降低毒性协同抗菌和杀虫，用于防治植物病菌和病虫害。旨在开发出可替代传统农用化学品的新型纳米农药。
作为项目负责人，获得国家自然科学基金6项，广东省自然科学基金重点项目及面上项目5项，广东省科技计划项目4项，广州市科技计划项目1项，中央高校基本业务费2项，卓越导师计划项目（高水平期刊论文）项目2项，暨南大学引进优秀人才科研启动基金1项。获得授权中国发明专利 16件。作为通讯作者已在Adv. Funct. Mater（IF 24.10,)，ACS Nano（IF 18.027），Biomaterials（IF 12.479)，Chemical Engineering Journal.（IF:16.7），Small (IF:15.153)，等本领域权威期刊发表SCI学术论文180余篇。2020年获得爱思唯尔高被引学者。
主要论文
2023年
1. Xiaoyu Yuan, Ran Tang, Zhi Jia, Yutong Chen, Jie Liu,*, Yanan Liu,*
Zn2+-Responsive Palladium Nanoclusters Synergistically Manage Alzheimer's Disease Through Neuroprotection and Inhibition of Oxidative Stress. Chemical Engineering Journal.2023
2. Xu Chen, Yonglan Yang , Gang Ye*, Shengming Liu*, Jie Liu*，Chiral ruthenium nanozymes with self-cascade reaction driven the NO generation induced macrophage M1 polarization realizing the lung cancer “Cocktail Therapy”. Small, 2023
2022年
1. Xufeng Zhu, Jiaqi Guo, Yonglan Yang, and Jie Liu.Macrophage Polarization Induced by Bacteria-Responsive Antibiotic-Loaded Nanozymes for Multidrug ResistanceBacterial Infections Management. Small 2022, 2204928, DOI: 10.1002/smll.202204928
2. Xiaoyu Yuan, Jieqiong Cen, Xu Chen, Zhi Jia, Xufeng Zhu, Yuqin Huang, Guanglong Yuan, Jie Liu*. Iridium oxide nanoparticles mediated enhanced photodynamic therapy combined with photothermal therapy in the treatment of breast cancer. Journal of Colloid and Interface Science. 2022, 605, 851-862，DOI: 10.1016/j.jcis.2021.07.136
3. Xu Chen, Zhi Jia, Yayu Wen, Yuqin Huang, Xiaoyu Yuan, Yutong Chen, Jie Liu*. Bidirectional anisotropic palladium nanozymes reprogram macrophages to enhance collaborative chemodynamic therapy of colorectal cancer. Acta biomaterialia 2022, 151, 537-548.
DOI: 10.1016/j.actbio.2022.08.020
4. Qianqian Yu, Yuqin Huang, Xu Chen, Yutong Chen, Xufeng Zhu, Yanan Liu, Jie Liu*. A neutrophil cell membrane-biomimetic nanoplatform based on L-arginine nanoparticles for early osteoarthritis diagnosis and nitric oxide therapy. Nanoscale 2022, 14, 11619. DOI: 10.1039/d2nr02601e
5. Yanan Liu, Yuqin Huang, Jiawei Liu, Jie Liu*. A temperature-responsive selenium nanohydrogel for strawberry grey mould management. Journal of Materials Chemistry B，2022, 10, 5231.
DOI: 10.1039/d2tb00345g
6. Yanan Liu, Junfang Huang, Jie Liu*. Single laser activated photothermal/photodynamic dual-modal cancer phototherapy by using ROS-responsive targeting flower-like ruthenium nanoparticles. Journal of Materials Chemistry B 2022,10, 7760. DOI: 10.1039/d2tb01276f
7. Jieqiong Cen, Yuqin Huang, Jie Liu * and Yanan Liu*. Thermo-responsive palladium–ruthenium nanozyme synergistic photodynamic therapy for metastatic breast cancer management. Journal of Materials Chemistry B, 2022,10,10027-10041. DOI:https://doi.org/10.1039/d2tb01481e
2021年
1. Youcong Gong, Anlian Huang, Xian Guo, Zhi Jia, Xu Chen, Xufeng Zhu, Yu Xia*, Jie Liu*, Ying Xu, Xiuying Qin . Selenium-core nanozymes dynamically regulates Aβ & neuroinflammation circulation: Augmenting repair of nervous damage. Chemical Engineering Journal. 2021, 418,129345，JCR一区，DOI: 10.1016/j.cej.2021.129345
2. Xu Chen, Xufeng Zhu, Youcong Gong, Guanglong Yuan, Jieqiong Cen, Qiaoshan Lie, Yida Hou, Gang Ye, Shengming Liu∗，Jie Liu∗. Porous selenium nanozymes targeted scavenging ROS synchronize therapy local inflammation and sepsis injury, Applied Materials Today, 2021, 22,100929，JCR一区，DOI:https://doi.org/10.1016/j.apmt.2020.100929
3. Xufeng Zhu, Xu Chen, Zhi Jia, Dongliang Huo, Yanan Liu, Jie Liu Cationic chitosan Ruthenium dioxide hybrid nanozymes for photothermal therapy enhancing ROS-mediated eradicating multidrug resistant bacterial infection，Journal of Colloid and Interface Science. 2021, 603,615-632. DOI: 10.1016/j.jcis.2021.06.073
4. Xufeng Zhu, Xu Chen, Dongliang Huo, Jieqiong Cen, Zhi Jia, Yanan Liu*, and Jie Liu*, A hybrid nanozymes in situ oxygen supply synergistic photothermal/chemotherapy of cancer management. Biomater. Sci., 2021, 9, 5330-5343
5. Xian Guo, Qiaoshan Lie, Yanan Liu, Zhi Jia, Youcong Gong, Xiaoyu Yuan, and Jie Liu*. Multifunctional Selenium Quantum Dots for the Treatment of Alzheimer’s Disease by Reducing Aβ-Neurotoxicity and Oxidative Stress and Alleviate Neuroinflammation. ACS Appl. Mater. Interfaces 2021, 13, 30261-30273. DOI: 10.1021/acsami.1c00690
6. Yanan Liu, Guanglong Yuan, Hairong Nan, Jieqiong Cen, Xufeng Zhu, Yanhui Zhou, Jie Liu*. Selenium nanoparticles with various morphology for antiangiogenesis through bFGF-mediated P13K/AKT signaling pathways, Nanotechnology, 2021, 32, 485102
7. Guanglong Yuan, Jieqiong Cen, Jiamin Liao, Yuqin Huang and Liu Jie*. In situ hydrogen nanogenerator for bimodal imaging guided synergistic photothermal/hydrogen therapies,
Nanoscale, 2021,13, 15576-15589. DOI: 10.1039/d1nr03260g
8. Xiaoyu Yuan, Zhi Jia, Jin Li*, Yanan Liu, Yuqin Huang, Youcong Gong,Xian Guo, Xu Chen, Jieqiong Cen and Jie Liu*. A diselenide bond-containing ROS-responsive ruthenium nanoplatform delivers nerve growth factor for Alzheimer’s disease management by repairing and promoting neuron regeneration. Journal of Materials Chemistry B，2021, 9, 7835–7847.
2021, 9, 7835-7847
9. Yanan Liu, Dongliang Huo, Xufeng Zhu,b Xu Chen, Ange Lin, Zhi Jia and Jie Liu*. A ruthenium nanoframe/enzyme composite system as a self-activating cascade agent for the treatment of bacterial infections. Nanoscale. 2021, 13, 14900-14914
10. Zhi Jia, Xiaoyu Yuan, Ji-an Wei, Xian Guo, Youcong Gong, Jin Li, Hui Zhou, Li Zhang,* and Jie Liu*. A Functionalized Octahedral Palladium Nanozyme as a Radical Scavenger for Ameliorating Alzheimer’s Disease. ACS Appl. Mater. Interfaces. 2021, 13, 49602-49613. DOI: 10.1021/acsami.1c06687
11. Yanan Liu, Jiawei Liu, Xiaoping Guo, Ange Lin, Yayu Wen, Xu Chen, Xufeng Zhu, Jie Liu, Zhaohui Luo, Photosensitive properties, synergistic antibacterial abilities of intelligent response-type self-assembled nanoparticle TiO2@V2O5. Journal of Biomaterials Applications, 2021, 35(6), 696-708. DOI：10.1177/0885328220940541journals.sagepub.com/home/jba
2020年
1. Jiawei Liu, Xufeng Zhu,Xu Chen, Yanan Liu, Youcong Gong, Guanglong Yuan, Jie Liu* and Lanmei Chen. Defense and inhibition integrated mesoporous nanoselenium delivery system against tomato gray mold，Environ. Sci. Nano, 2020, 7, 210–227，DOI: 10.1039/c9en00859drsc.li/es-nano
2. Xufeng Zhu, Youcong Gong, Yanan Liu, Chunhua Yang, Sijie Wu, Guanglong Yuan, Xian Guo, Jie Liu∗, Xiuying Qin. Ru@CeO2 yolk shell nanozymes: Oxygen supply in situ enhanced dual chemotherapy combined with photothermal therapy for orthotopic/subcutaneous colorectal cancer. Biomaterials，2020, 242,119922- 119923.
3. ChunfangWei, YananLiu, XufengZhu, XuChen, YanhuiZhou, GuanglongYuan, YoucongGong, JieLiu,* Iridium/ruthenium nanozyme reactors with cascade catalytic ability for synergistic oxidation therapy and starvation therapy in the treatment of breast cancer. Biomaterials, 2020, 238,119848. https://doi.org/10.1016/j.biomaterials.2020.119848，
4. Hui Zhou, Youcong Gong, Yanan Liu, Anlian Huang, Xufeng Zhu, Jiawei Liu, Guanglong Yuan, Li Zhang, Ji-an Wei, Jie Liu* Intelligently thermoresponsive flower-like hollow nano-ruthenium system for sustained release of nerve growth factor to inhibit hyperphosphorylation of tau and neuronal damage for the treatment of Alzheimer's disease. Biomaterials, 2020, 237, 119822, https://doi.org/10.1016/j.biomaterials.2020.119822
5.Yanan Liu, Youcong Gong, Wenjie Xie, Anlian Huang, Xiaoyu Yuan, Hui Zhou, Xufeng Zhu, Xu Chen, Jiawei Liu, Jie Liu*, and Xiuying Qin*. Microbubbles in combination with focused ultrasound for the delivery of quercetin-modified sulfur nanoparticles through the blood brain barrier into the brain parenchyma and relief of endoplasmic reticulum stress to treat Alzheimer’s disease. Nanoscale, 2020, 12, 6498- 6511. DOI: 10.1039/c9nr09713a
6. Xufeng Zhu, Yanan Liu, Guanglong Yuan, Xian Guo, Jieqiong Cen, Youcong Gong, Jie Liu* and Ye Gang*. In situ fabrication of MS@MnO2 hybrid as nanozymes for enhancing ROS-mediated breast cancer therapy. Nanoscale, 2020, 12, 22317
7.Yanan Liu, Chunfang Wei, Ange Lin, Jiali Pan, Xu Chen, Xufeng Zhu, Youcong Gong, Guanglong Yuan, Lanmei Chen, Jie Liu*, Zhaohui Luo,*Responsive functionalized MoSe2 nanosystem for highly efficient synergistic therapy of breast cancer. Colloids and Surfaces B: Biointerfaces 189 (2020) 110820.
2019年
1. Jing Sun, Chunfang Wei, Yanan Liu∗, Wenjie Xie, Mengmeng Xu, Hui Zhou, Jie Liu∗. Progressive release of mesoporous nano-selenium delivery system for the multi-channel synergistic treatment of Alzheimer's disease, Biomaterials 2019,197,417-431.
2. Xu Chen, Xufeng Zhu,Taoyuan Xu, Mengmeng Xu,Yayu Wen, Yanan Liu,*Jie Liu* and Xiuying Qin*.Targeted hexagonal Pd nanosheet combination therapy for rheumatoid arthritis via the photothermal controlled release of MTX, J. Mater. Chem. B, 2019,7,112-122.
3. Yanan Liu, Meng Xu, Yingyu Zhao, Xu Chen, Xufeng Zhu,Chunfang Wei, Shuang Zhao, Jie Liu*, Xiuying Qin*. Flower-like gold nanoparticles for enhanced photothermal anticancer therapy by the delivery of pooled siRNA to inhibit heat shock stress response, J. Mater. Chem. B, 2019, 7, 586-597.
4. Xu Chen, Yanan Liu, Yayu Wen, Qianqian Yu, Jiawei Liu, Yingyu Zhao, Jie Liu*, Gang Ye*. Photothermal-triggered Nitric oxide Nanogenerator Combined with siRNA Precise Therapy Osteoarthritis by Suppressing Macrophage Inflammation, Nanoscale, 2019, 11, 6693-6709.
5. Yingyu Zhao, Chunfang Wei, Xu Chen, Jiawei Liu, Qianqian Yu, Yanan Liu* and Jie Liu*. Drug Delivery System Based on Near-Infrared Light-Responsive Molybdenum Disulfide Nanosheets Controls the High-Efficiency Release of Dexamethasone To Inhibit Inflammation and Treat Osteoarthritis, ACS Appl. Mater. Interfaces 2019, 11, 11587-11601.
6. Yanan Liu a,b,1, Hui Zhou a,b,1, Tiantian Yinb, Youcong Gongb, Guanglong Yuanb, Lanmei Chena,*,Jie Liua,b*,Quercetin-modified gold-palladium nanoparticles as a potential autophagy inducer for the treatment of Alzheimer's disease，Journal of Colloid and Interface Science,2019, 552, 388-400.
7. Xufeng Zhu$, Yayu Wen$, Yingyu Zhao, Yanan Liu, Jing Sun,Jiawei Liu, Jie Liu* and Lanmei Chen*,Functionalized chitosan-modified defectrelated luminescent mesoporous silica nanoparticles as new inhibitors for Hiapp aggregation, Nanotechnology ,2019, 30, 315705-315716.
8. Meng Xu,‡a Yayu Wen,‡a Yanan Liu,*a Xianjie Tan,a Xu Chen,a Xufeng Zhu,a Chunfang Wei,a Lanmei Chen,*b Zhong Wangc and Jie Liu*a. Hollow Mesoporous Ruthenium Nanoparticles Conjugated Bispecific Antibody for Targeted Anti-Colorectal Cancer Response of Combination Therapy, Nanoscale, 2019, 11, 9661-9678.
9. Yanan Liu+, Jing Sun+, Youcong Gong, Hui Zhou, Xu Chen, Xufeng Zhu, Yingyu Zhao, Yayu Wen, Xiuying Qin, and Jie Liu*. Peptide-Modified Mo Polyoxometalate Nanoparticles Suppress Zn2+-Induced Aβ Aggregation. ChemNanoMat 2019, 5, 897-910
10. Yanan Liu, Ange Lin, Jiawei Liu, Xu Chen, Xufeng Zhu, Youcong Gong, Guanglong Yuan , Lanmei Chen*, Jie Liu* Enzyme-responsive mesoporous ruthenium for combined chemo-photothermal therapy of drug-resistant bacteria. ACS Appl. Mater. Interfaces 2019, 11, 26590-26606
11. Xu Chen, Xufeng Zhu, Litao Ma, Ange Lin, Youcong Gong, Guanglong Yuan and Jie Liu*. A core–shell structure QRu-PLGA-RES-DS NP nanocomposite with photothermal responseinduced M2 macrophage polarization for rheumatoid arthritis therapy Nanoscale，Nanoscale, 2019, 11, 18209-18223
12. Yanan Liu, Yayu Wen, Xu Chen, Xufeng Zhu, Qianqian Yu, Youcong Gong,Guanglong Yuan, Jie Liu*, Xiuying Qin. Inflammation-responsive functional Ru nanoparticles combining a tumor-associated macrophage repolarization strategy with phototherapy for colorectal cancer therapy. J. Mater. Chem. B, 2019, 7, 6210-6223
13. Ange Lin, Yanan Liu, Xufeng Zhu, Xu Chen, Jiawei Liu, Yanhui Zhou, Xiuying Qin, and Jie Liu*.Bacteria-Responsive Biomimetic Selenium Nanosystem for Multidrug-Resistant Bacterial Infection Detection and Inhibition. ACS Nano 2019, 13, 13965−13984, DOI: 10.1021/acsnano.9b05766
14. Yayu Wen, Xu Chen, Xufeng Zhu, Youcong Gong, Guanglong Yuan, Xiuying Qin, and Jie Liu*, Photothermal-Chemotherapy Integrated Nanoparticles with Tumor Microenvironment Response Enhanced the Induction of Immunogenic Cell Death for Colorectal Cancer Efficient Treatment. ACS Appl. Mater. Interfaces 2019, 11, 43393−43408. DOI: 10.1021/acsami.9b17137
承担课题
作为项目负责人，获得国家自然科学基金6项，广东省自然科学基金重点项目及面上项目等6项，广东省科技计划项目4项，广州市科技计划项目1项，中央高校基本业务费2项，卓越导师计划项目（高水平期刊论文）项目2项，太阳集团城娱8722引进优秀人才科研启动基金1项。获得授权中国发明专利16件。
1. “三效合一”仿生纳米酶靶向细菌诱导巨噬细胞极化治疗耐药细菌感染，国家自然科学基金，项目负责人，22277041，2023.01.01-2026.12.31
2. 仿生纳米酶用于检测和对抗耐药性细菌感染的研究，广东省自然科学基金，项目负责人，
2022A1515012074，2022-01-01-2024.12.31
3. 微泡及超声介导BBB开放递送纳米硒/硫及其载药抑制阿尔兹海默病的研究，国家自然科学基金，项目负责人，21877051， 2019.01-2022.12
4. 双靶点抑制血管生成和肿瘤的钌功能化纳米硒及其细胞吸收机制的研究
国家自然科学基金，项目负责人，21371075， 2014/1/1-2017/12/31
5. 基于单细胞成像研究钌配合物作为识别肿瘤细胞的荧光探针和对凋亡信号通路的影响，国家自然科学基金21171070，项目负责人， 2012.01-2015.12
6. 钌配合物在肺癌细胞中调控p53表达及对Survivin通路的影响，国家自然科学基金20871056，项目主持人， 2009.01-2011.12
7. 钌配合物诱导肺癌A549细胞的凋亡及对细胞端粒酶活性的影响，国家自然科学基金，20471070，项目主持人，2005.01-2007.12
讲授课程
主要讲授“无机化学”，“配位化学”等课程。
荣誉与奖励：广东省科学技术奖励，一等奖（排名第5），2012年；获得太阳集团城娱8722首届十佳优秀教师，太阳集团城娱8722本科教学董事长奖，太阳集团城娱8722“我最喜爱的化材教师”等。指导博士硕士研究生15人次获得国家奖学金，3人获得太阳集团城娱8722博士生攀登计划，9人获得太阳集团城娱8722优秀博士、硕士论文，2人获得广东省优秀研究生。指导的本科生获得国家创新创业大赛优秀论文奖，广东省科技创新战略专项资金，国家级创新创业训练项目，广东大员工材料创新大赛获奖等。
